Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery

Physiologically-based pharmacokinetic (PBPK) modeling is a popular drug development tool that integrates physiology, drug physicochemical properties, preclinical data, and clinical information to predict drug systemic disposition. Since PBPK models seek to capture complex physiology, parameter uncer...

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Detalles Bibliográficos
Autores principales: Talkington, Anne M., Wessler, Timothy, Lai, Samuel K., Cao, Yanguang, Forest, M. Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576315/
https://www.ncbi.nlm.nih.gov/pubmed/34751832
http://dx.doi.org/10.1007/s11538-021-00950-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576315/
https://www.ncbi.nlm.nih.gov/pubmed/34751832
http://dx.doi.org/10.1007/s11538-021-00950-z

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