TRPA1 promotes cisplatin-induced nephrotoxicity through inflammation mediated by the MAPK/NF-κB signaling pathway

BACKGROUND: The nephrotoxicity induced by cisplatin (DDP) has been a severe obstacle for its clinical use in anticancer treatment. The apoptosis and inflammation induced by DDP are the main causes of the nephrotoxicity. Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation ligand-...

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Detalles Bibliográficos
Autores principales: Yuan, Jinyan, Liang, Xiao, Zhou, Wei, Feng, Jing, Wang, Zhenyang, Shen, Shaoxian, Guan, Xin, Zhao, Liangbin, Deng, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576655/
https://www.ncbi.nlm.nih.gov/pubmed/34790784
http://dx.doi.org/10.21037/atm-21-5125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576655/
https://www.ncbi.nlm.nih.gov/pubmed/34790784
http://dx.doi.org/10.21037/atm-21-5125

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