MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway

BACKGROUND: Phosphodiesterase 4D (PDE4D) inhibitor is commonly used to treat depression, but side effects seriously decrease its efficacy. PDE4D was a downstream target mRNA of miR-139-5p. Therefore, we examined the effects of hippocampal miR-139-5p gain- and loss-of-function on depression-like beha...

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Detalles Bibliográficos
Autores principales: Huang, Peng, Wei, Songren, Luo, Meng, Tang, Zhuohong, Lin, Qingmei, Wang, Xing, Luo, Mi, He, Yanjun, Wang, Chuan, Wei, Dezhan, Xia, Chenglai, Xu, Jiangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576692/
https://www.ncbi.nlm.nih.gov/pubmed/34790800
http://dx.doi.org/10.21037/atm-21-5149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576692/
https://www.ncbi.nlm.nih.gov/pubmed/34790800
http://dx.doi.org/10.21037/atm-21-5149

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