Hippocampal CysLT1R overexpression or activation accelerates memory deficits, synaptic dysfunction, and amyloidogenesis in young APP/PS1 transgenic mice

BACKGROUND: Our previous studies demonstrated that cysteinyl leukotrienes receptor 1 (CysLT(1)R) knockout, pharmacological blockade, or hippocampus knockdown produced beneficial effects against Alzheimer’s disease (AD); however, whether CysLT(1)R upregulation has deleterious effects on AD remains el...

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Detalles Bibliográficos
Autores principales: Fang, Shun-Chang, Wang, Jun-Jie, Chen, Fang, Tang, Su-Su, Mu, Rong-Hao, Yuan, Dan-Hua, Zhao, Jia-Jia, Hong, Hao, Long, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576703/
https://www.ncbi.nlm.nih.gov/pubmed/34790737
http://dx.doi.org/10.21037/atm-21-4518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576703/
https://www.ncbi.nlm.nih.gov/pubmed/34790737
http://dx.doi.org/10.21037/atm-21-4518

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