Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation

[Image: see text] A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pK(a) promotes fragmentation even at...

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Detalles Bibliográficos
Autores principales: Ferhati, Xhenti, Salas-Cubero, Marina, Garrido, Pablo, García-Sanmartín, Josune, Guerreiro, Ana, Avenoza, Alberto, Busto, Jesús H., Peregrina, Jesús M., Martínez, Alfredo, Jiménez-Moreno, Ester, Bernardes, Gonçalo J. L., Corzana, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576835/
https://www.ncbi.nlm.nih.gov/pubmed/34694118
http://dx.doi.org/10.1021/acs.orglett.1c03299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576835/
https://www.ncbi.nlm.nih.gov/pubmed/34694118
http://dx.doi.org/10.1021/acs.orglett.1c03299

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