Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in leucine rich repeat kinase 2 (LRRK2) are the most common genetic cause of PD. Lewy pathology is found in the majority of individuals with LRRK2-PD, particula...

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Detalles Bibliográficos
Autores principales: Brzozowski, Charlotte F., Hijaz, Baraa A., Singh, Vijay, Gcwensa, Nolwazi Z., Kelly, Kaela, Boyden, Edward S., West, Andrew B., Sarkar, Deblina, Volpicelli-Daley, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576889/
https://www.ncbi.nlm.nih.gov/pubmed/34749824
http://dx.doi.org/10.1186/s40478-021-01283-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576889/
https://www.ncbi.nlm.nih.gov/pubmed/34749824
http://dx.doi.org/10.1186/s40478-021-01283-7

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