Cargando…

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in leucine rich repeat kinase 2 (LRRK2) are the most common genetic cause of PD. Lewy pathology is found in the majority of individuals with LRRK2-PD, particula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brzozowski, Charlotte F., Hijaz, Baraa A., Singh, Vijay, Gcwensa, Nolwazi Z., Kelly, Kaela, Boyden, Edward S., West, Andrew B., Sarkar, Deblina, Volpicelli-Daley, Laura A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576889/ https://www.ncbi.nlm.nih.gov/pubmed/34749824 http://dx.doi.org/10.1186/s40478-021-01283-7

Ejemplares similares

Molecular Mechanisms Underlying Synaptic and Axon Degeneration in Parkinson’s Disease
por: Gcwensa, Nolwazi Z., et al.
Publicado: (2021)

Initiation and propagation of α-synuclein aggregation in the nervous system
por: Hijaz, Baraa A., et al.
Publicado: (2020)

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
por: Xu, Enquan, et al.
Publicado: (2022)

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
por: Volpicelli-Daley, Laura A., et al.
Publicado: (2014)

Anterograde Axonal Transport in Neuronal Homeostasis and Disease
por: Guillaud, Laurent, et al.
Publicado: (2020)

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
por: Zhao, Hien Tran, et al.
Publicado: (2017)

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
por: Zhao, Hien Tran, et al.
Publicado: (2021)

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
por: Zhao, Hien Tran, et al.
Publicado: (2021)

α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword
por: Tan, Li Yang, et al.
Publicado: (2022)

Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics
por: Kelly, Kaela, et al.
Publicado: (2020)

Labeling Dual Presynaptic Inputs using cFork Anterograde Tracing System
por: Oh, Jun-Young, et al.
Publicado: (2020)

In Vivo Imaging of Anterograde and Retrograde Axonal Transport in Rodent Peripheral Nerves
por: Sleigh, James N., et al.
Publicado: (2020)

Independent anterograde transport and retrograde cotransport of domain components of myelinated axons
por: Bekku, Yoko, et al.
Publicado: (2020)

Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation
por: Mezias, Christopher, et al.
Publicado: (2019)

Role of Us9 Phosphorylation in Axonal Sorting and Anterograde Transport of Pseudorabies Virus
por: Kratchmarov, Radomir, et al.
Publicado: (2013)

Exosome markers of LRRK2 kinase inhibition
por: Wang, Shijie, et al.
Publicado: (2020)

The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles
Publicado: (1980)

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport
por: Steuble, Martin, et al.
Publicado: (2012)

Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport
por: Wu, Youjun, et al.
Publicado: (2023)

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
por: Sarkar, Souvarish, et al.
Publicado: (2021)

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport
por: Chiba, Kyoko, et al.
Publicado: (2014)

Uptake and anterograde axonal transport of wheat germ agglutinin from retina to optic tectum in the chick
Publicado: (1981)

The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
por: Kawakami, Fumitaka, et al.
Publicado: (2015)

Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons
por: Sabui, Anusruti, et al.
Publicado: (2022)

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease
por: Gracia, Pablo, et al.
Publicado: (2020)

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
por: Palomo-Guerrero, Marta, et al.
Publicado: (2019)

Visualization of an Alphaherpesvirus Membrane Protein That Is Essential for Anterograde Axonal Spread of Infection in Neurons
por: Taylor, M. P., et al.
Publicado: (2012)

Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models
por: Manich, Gemma, et al.
Publicado: (2020)

MicroRNAs in the axon and presynaptic nerve terminal
por: Kaplan, Barry B., et al.
Publicado: (2013)

Editorial: Control of Presynaptic Function by Axonal Dynamics
por: Trigo, Federico F., et al.
Publicado: (2019)

KIF3A is a new microtubule-based anterograde motor in the nerve axon
Publicado: (1994)

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
por: O’Hara, Darren M., et al.
Publicado: (2020)

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking
por: Ogawa, Fumiaki, et al.
Publicado: (2014)

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila
por: Bridi, Jessika C, et al.
Publicado: (2021)

Dual Effects of Presynaptic Membrane Mimetics on α-Synuclein Amyloid Aggregation
por: Lin, Yuxi, et al.
Publicado: (2022)

Two kinesins drive anterograde neuropeptide transport
por: Lim, Angeline, et al.
Publicado: (2017)

Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils
por: Redmann, Matthew, et al.
Publicado: (2017)

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons
por: Anderson, Eric N., et al.
Publicado: (2020)

Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons
por: Hamada, Mustafa S., et al.
Publicado: (2017)

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels
por: Moller, Annekathrin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hv82d438o6rfpnqo0ge0ujhdl0