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Constructing germline research cohorts from the discarded reads of clinical tumor sequences

BACKGROUND: Hundreds of thousands of cancer patients have had targeted (panel) tumor sequencing to identify clinically meaningful mutations. In addition to improving patient outcomes, this activity has led to significant discoveries in basic and translational domains. However, the targeted nature of...

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Detalles Bibliográficos
Autores principales: Gusev, Alexander, Groha, Stefan, Taraszka, Kodi, Semenov, Yevgeniy R., Zaitlen, Noah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576948/
https://www.ncbi.nlm.nih.gov/pubmed/34749793
http://dx.doi.org/10.1186/s13073-021-00999-4