A lysosome-targeted dextran-doxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia

The hypoxic microenvironment is presumed to be a sanctuary for myeloid leukemia cells that causes relapse following chemotherapy, but the underlying mechanism remains elusive. Using a zebrafish xenograft model, we observed that the hypoxic hematopoietic tissue preserved most of the chemoresistant le...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Yunxin, Zhang, Xinyu, Lin, Dongjun, Feng, Xiaohui, Liu, Yuye, Fang, Zhengwen, Zhang, Weijian, Chen, Yu, Zhao, Meng, Wu, Jun, Jiang, Linjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576957/
https://www.ncbi.nlm.nih.gov/pubmed/34749790
http://dx.doi.org/10.1186/s13045-021-01199-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576957/
https://www.ncbi.nlm.nih.gov/pubmed/34749790
http://dx.doi.org/10.1186/s13045-021-01199-8

Ejemplares similares