Cargando…

Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes

OBJECTIVES: pDCs and γδ T cells emerge as potent immune players participating in the pathophysiology of cancers, yet still remaining enigmatic while harbouring a promising potential for clinical translations. Despite strategic and closed missions, crosstalk between pDCs and γδ T cells has not been d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Girard, Pauline, Sosa Cuevas, Eleonora, Ponsard, Benedicte, Mouret, Stephane, Gil, Hugo, Col, Edwige, De Fraipont, Florence, Sturm, Nathalie, Charles, Julie, Manches, Olivier, Chaperot, Laurence, Aspord, Caroline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577077/ https://www.ncbi.nlm.nih.gov/pubmed/34786191 http://dx.doi.org/10.1002/cti2.1329

Ejemplares similares

Potent Bidirectional Cross-Talk Between Plasmacytoid Dendritic Cells and γδT Cells Through BTN3A, Type I/II IFNs and Immune Checkpoints
por: Girard, Pauline, et al.
Publicado: (2020)

BDCA1(+) cDC2s, BDCA2(+) pDCs and BDCA3(+) cDC1s reveal distinct pathophysiologic features and impact on clinical outcomes in melanoma patients
por: Sosa Cuevas, Eleonora, et al.
Publicado: (2020)

The melanoma tumor glyco-code impacts human dendritic cells’ functionality and dictates clinical outcomes
por: Sosa Cuevas, Eleonora, et al.
Publicado: (2023)

Hepatitis B virus exploits C‐type lectin receptors to hijack cDC1s, cDC2s and pDCs
por: Ouaguia, Laurissa, et al.
Publicado: (2020)

Diversification of circulating and tumor‐infiltrating plasmacytoid DCs towards the P3 (CD80(+) PDL1(−))‐pDC subset negatively correlated with clinical outcomes in melanoma patients
por: Sosa Cuevas, Eleonora, et al.
Publicado: (2022)

Innate sensing of viral infection by pDCs and regulation by IFN-α and HMGB1 of TRAIL expression on pDCs and NK cells
por: Saïdi, Héla, et al.
Publicado: (2014)

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology
por: Vantourout, Pierre, et al.
Publicado: (2018)

Phenotypic and functional alterations of pDCs in lupus-prone mice
por: Zhou, Zhenyuan, et al.
Publicado: (2016)

New Insights Into the Regulation of γδ T Cells by BTN3A and Other BTN/BTNL in Tumor Immunity
por: Blazquez, Juan-Luis, et al.
Publicado: (2018)

IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
por: Lippens, Carla, et al.
Publicado: (2016)

Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment
por: Kacher, Jamila, et al.
Publicado: (2022)

NK-pDC cross-talk leads to the generation of mTRAIL+IFN-α+cytotoxic pDCs following HIV-1 infection of pDCs. Consequences on the control of viral replication
por: Saïdi, Héla, et al.
Publicado: (2010)

Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
por: Jiao, Yanmei, et al.
Publicado: (2014)

Data on PRRSV infection promoted the subtype of porcine dendritic cells from mDCs to pDCs in vivo
por: Liu, Jinling, et al.
Publicado: (2016)

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses
por: Chaudhary, Vidyanath, et al.
Publicado: (2022)

Extended Freeze-Dried BCG Instructed pDCs Induce Suppressive Tregs and Dampen EAE
por: Lippens, Carla, et al.
Publicado: (2018)

Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs
por: Ma, Shixin, et al.
Publicado: (2017)

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
por: Shimizu, Kanako, et al.
Publicado: (2019)

P16-52. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism
por: Manches, O, et al.
Publicado: (2009)

Unique CLR expression patterns on circulating and tumor-infiltrating DC subsets correlated with clinical outcome in melanoma patients
por: Sosa Cuevas, Eleonora, et al.
Publicado: (2022)

New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
por: Guéry, Leslie, et al.
Publicado: (2015)

Physical Exercise Induces Immunoregulation of TREG, M2, and pDCs in a Lung Allergic Inflammation Model
por: Fernandes, Paula, et al.
Publicado: (2019)

Lack of Association Between Sex Hormones, MDSCs, LDGs and pDCs in Males and Females With Systemic Lupus Erythematosus
por: Jones, Jessica M., et al.
Publicado: (2022)

Plasmacytoid Dendritic cells (pDCs) in HIV-infected and HIV/HCV-co-infected patients receiving successful treatment
por: Khokhlova, Olga, et al.
Publicado: (2014)

CSL362 potently and specifically depletes pDCs invitro and ablates SLE-immune complex-induced IFN responses
por: Monaghan, Katherine A., et al.
Publicado: (2023)

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters
por: Rhodes, David A., et al.
Publicado: (2018)

Neonatal Plasmacytoid Dendritic Cells (pDCs) Display Subset Variation but Can Elicit Potent Anti-Viral Innate Responses
por: Zhang, Xiaoming, et al.
Publicado: (2013)

Activation of Human γδ T Cells by Cytosolic Interactions of BTN3A1 with Soluble Phosphoantigens and the Cytoskeletal Adaptor Periplakin
por: Rhodes, David A., et al.
Publicado: (2015)

Analysis of macaque BTN3A genes and transcripts in the extended MHC: conserved orthologs of human γδ T cell modulators
por: de Groot, Nanine, et al.
Publicado: (2019)

Emergence of IFN-alpha TRAIL-expressing killer pDCs (IKpDCs) as a consequence of a crosstalk with NK cells. Influence of HIV-1 infection and implication of HMGB1
por: Bras, Marlène, et al.
Publicado: (2012)

Altered expression of Butyrophilin (BTN) and BTN‐like (BTNL) genes in intestinal inflammation and colon cancer
por: Lebrero‐Fernández, Cristina, et al.
Publicado: (2016)

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment
por: Smith, Nikaïa, et al.
Publicado: (2019)

Mesenchymal Stem Cells Alleviate Moderate-to-Severe Psoriasis by Reducing the Production of Type I Interferon (IFN-I) by Plasmacytoid Dendritic Cells (pDCs)
por: Chen, Maosheng, et al.
Publicado: (2019)

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
por: Laurent, Paôline, et al.
Publicado: (2022)

Mutation in Irf8 Gene (Irf8(R294C) ) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs
por: Das, Annesa, et al.
Publicado: (2021)

Activation status of γδ T cells dictates their effect on osteoclast generation and bone resorption
por: Phalke, Swati P., et al.
Publicado: (2015)

Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast
por: Kanneganti, Vydehi, et al.
Publicado: (2011)

Sedimentation and mobility of PDCs: a reappraisal of ignimbrites’ aspect ratio
por: Giordano, Guido, et al.
Publicado: (2017)

Relationships between IL-17(+) Subsets, Tregs and pDCs That Distinguish among SIV Infected Elite Controllers, Low, Medium and High Viral Load Rhesus Macaques
por: Khowawisetsut, Ladawan, et al.
Publicado: (2013)

Investigation of the intramolecular hydrogen bonding interactions and excited state proton transfer mechanism for both Br-BTN and CN-BTN systems
por: Yang, Dapeng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ctfjdvh3ct3ib71pm3bp8sa038