Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes

Preclinical drug candidates are screened for their ability to ameliorate in vitro neuronal electrophysiology, and go/no-go decisions progress drugs to clinical trials based on population means across cells and animals. However, these measures do not mitigate clinical endpoint risk. Population-based...

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Detalles Bibliográficos
Autores principales: Allam, Sushmita L., Rumbell, Timothy H., Hoang-Trong, Tuan, Parikh, Jaimit, Kozloski, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577087/
https://www.ncbi.nlm.nih.gov/pubmed/34778727
http://dx.doi.org/10.1016/j.isci.2021.103279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577087/
https://www.ncbi.nlm.nih.gov/pubmed/34778727
http://dx.doi.org/10.1016/j.isci.2021.103279

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