Cargando…
Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes
Preclinical drug candidates are screened for their ability to ameliorate in vitro neuronal electrophysiology, and go/no-go decisions progress drugs to clinical trials based on population means across cells and animals. However, these measures do not mitigate clinical endpoint risk. Population-based...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577087/ https://www.ncbi.nlm.nih.gov/pubmed/34778727 http://dx.doi.org/10.1016/j.isci.2021.103279 |