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Mechanistic roles of tyrosine phosphorylation in reversible amyloids, autoinhibition, and endosomal membrane association of ALIX

Human apoptosis-linked gene-2 interacting protein X (ALIX), a versatile adapter protein, regulates essential cellular processes by shuttling between late endosomal membranes and the cytosol, determined by its interactions with Src kinase. Here, we investigate the molecular basis of these transitions...

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Detalles Bibliográficos
Autores principales: Elias, Ruben D., Ramaraju, Bhargavi, Deshmukh, Lalit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577116/
https://www.ncbi.nlm.nih.gov/pubmed/34688656
http://dx.doi.org/10.1016/j.jbc.2021.101328