Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report

The success of immune checkpoint inhibitors in metastatic renal cell carcinoma (RCC) has renewed interest in studying these agents in preoperative settings. Here, we present a case of metastatic RCC with an inferior vena cava (IVC) tumor thrombus extending to the right atrium. Preoperative systemic...

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Autores principales: Otsuka, Hikari, Masui, Kimihiko, Hosomi, Toshihide, Makino, Yuki, Shibasaki, Noboru, Shichiri, Yasumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577410/
https://www.ncbi.nlm.nih.gov/pubmed/34777999
http://dx.doi.org/10.1016/j.eucr.2021.101912
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author Otsuka, Hikari
Masui, Kimihiko
Hosomi, Toshihide
Makino, Yuki
Shibasaki, Noboru
Shichiri, Yasumasa
author_facet Otsuka, Hikari
Masui, Kimihiko
Hosomi, Toshihide
Makino, Yuki
Shibasaki, Noboru
Shichiri, Yasumasa
author_sort Otsuka, Hikari
collection PubMed
description The success of immune checkpoint inhibitors in metastatic renal cell carcinoma (RCC) has renewed interest in studying these agents in preoperative settings. Here, we present a case of metastatic RCC with an inferior vena cava (IVC) tumor thrombus extending to the right atrium. Preoperative systemic therapy with ipilimumab/nivolumab was initiated for four cycles. The IVC tumor thrombus level was significantly downstaged from IV to I according to the Mayo classification, which enabled us to perform cytoreductive nephrectomy and IVC thrombectomy without extracorporeal circulation. Preoperative ipilimumab/nivolumab may lead to significant downstaging of caval tumor thrombus in metastatic RCC.
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spelling pubmed-85774102021-11-12 Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report Otsuka, Hikari Masui, Kimihiko Hosomi, Toshihide Makino, Yuki Shibasaki, Noboru Shichiri, Yasumasa Urol Case Rep Oncology The success of immune checkpoint inhibitors in metastatic renal cell carcinoma (RCC) has renewed interest in studying these agents in preoperative settings. Here, we present a case of metastatic RCC with an inferior vena cava (IVC) tumor thrombus extending to the right atrium. Preoperative systemic therapy with ipilimumab/nivolumab was initiated for four cycles. The IVC tumor thrombus level was significantly downstaged from IV to I according to the Mayo classification, which enabled us to perform cytoreductive nephrectomy and IVC thrombectomy without extracorporeal circulation. Preoperative ipilimumab/nivolumab may lead to significant downstaging of caval tumor thrombus in metastatic RCC. Elsevier 2021-10-23 /pmc/articles/PMC8577410/ /pubmed/34777999 http://dx.doi.org/10.1016/j.eucr.2021.101912 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Otsuka, Hikari
Masui, Kimihiko
Hosomi, Toshihide
Makino, Yuki
Shibasaki, Noboru
Shichiri, Yasumasa
Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report
title Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report
title_full Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report
title_fullStr Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report
title_full_unstemmed Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report
title_short Preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: A case report
title_sort preoperative ipilimumab/nivolumab combination therapy reduced operation risk by downstaging the inferior vena cava tumor thrombus extending to the right atrium in a metastatic renal cell carcinoma: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577410/
https://www.ncbi.nlm.nih.gov/pubmed/34777999
http://dx.doi.org/10.1016/j.eucr.2021.101912
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