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Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure

OBJECTIVE AND HYPOTHESIS: Klotho is an aging-suppressor gene. Mutation of Klotho gene causes hyperphosphatemia and acute heart failure. However, the relationship of hyperphosphatemia and acute heart failure is unclear. We hypothesize that hyperphosphatemia mediates Klotho deficiency-induced acute he...

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Detalles Bibliográficos
Autores principales: Chen, Kai, Sun, Zhongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577443/
https://www.ncbi.nlm.nih.gov/pubmed/34678656
http://dx.doi.org/10.1016/j.redox.2021.102173