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Short-chain fatty acids as modulators of redox signaling in health and disease
Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the act...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577496/ https://www.ncbi.nlm.nih.gov/pubmed/34662811 http://dx.doi.org/10.1016/j.redox.2021.102165 |
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author | González-Bosch, Carmen Boorman, Emily Zunszain, Patricia A. Mann, Giovanni E. |
author_facet | González-Bosch, Carmen Boorman, Emily Zunszain, Patricia A. Mann, Giovanni E. |
author_sort | González-Bosch, Carmen |
collection | PubMed |
description | Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying SCFAs mediated protection against oxidative and mitochondrial stress and their role in regulating metabolic pathways in specific tissues. We critically evaluate the evidence for their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging. The ability of these natural compounds to induce signaling pathways, involving nuclear erythroid 2-related factor 2 (Nrf2), contributes to the maintenance of redox homeostasis under physiological conditions. SCFAs may thus serve as nutritional and therapeutic agents in healthy aging and in vascular and other diseases such as diabetes, neuropathologies and cancer. |
format | Online Article Text |
id | pubmed-8577496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85774962021-11-15 Short-chain fatty acids as modulators of redox signaling in health and disease González-Bosch, Carmen Boorman, Emily Zunszain, Patricia A. Mann, Giovanni E. Redox Biol Review Article Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying SCFAs mediated protection against oxidative and mitochondrial stress and their role in regulating metabolic pathways in specific tissues. We critically evaluate the evidence for their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging. The ability of these natural compounds to induce signaling pathways, involving nuclear erythroid 2-related factor 2 (Nrf2), contributes to the maintenance of redox homeostasis under physiological conditions. SCFAs may thus serve as nutritional and therapeutic agents in healthy aging and in vascular and other diseases such as diabetes, neuropathologies and cancer. Elsevier 2021-10-14 /pmc/articles/PMC8577496/ /pubmed/34662811 http://dx.doi.org/10.1016/j.redox.2021.102165 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article González-Bosch, Carmen Boorman, Emily Zunszain, Patricia A. Mann, Giovanni E. Short-chain fatty acids as modulators of redox signaling in health and disease |
title | Short-chain fatty acids as modulators of redox signaling in health and disease |
title_full | Short-chain fatty acids as modulators of redox signaling in health and disease |
title_fullStr | Short-chain fatty acids as modulators of redox signaling in health and disease |
title_full_unstemmed | Short-chain fatty acids as modulators of redox signaling in health and disease |
title_short | Short-chain fatty acids as modulators of redox signaling in health and disease |
title_sort | short-chain fatty acids as modulators of redox signaling in health and disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577496/ https://www.ncbi.nlm.nih.gov/pubmed/34662811 http://dx.doi.org/10.1016/j.redox.2021.102165 |
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