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Short-chain fatty acids as modulators of redox signaling in health and disease

Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the act...

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Autores principales: González-Bosch, Carmen, Boorman, Emily, Zunszain, Patricia A., Mann, Giovanni E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577496/
https://www.ncbi.nlm.nih.gov/pubmed/34662811
http://dx.doi.org/10.1016/j.redox.2021.102165
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author González-Bosch, Carmen
Boorman, Emily
Zunszain, Patricia A.
Mann, Giovanni E.
author_facet González-Bosch, Carmen
Boorman, Emily
Zunszain, Patricia A.
Mann, Giovanni E.
author_sort González-Bosch, Carmen
collection PubMed
description Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying SCFAs mediated protection against oxidative and mitochondrial stress and their role in regulating metabolic pathways in specific tissues. We critically evaluate the evidence for their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging. The ability of these natural compounds to induce signaling pathways, involving nuclear erythroid 2-related factor 2 (Nrf2), contributes to the maintenance of redox homeostasis under physiological conditions. SCFAs may thus serve as nutritional and therapeutic agents in healthy aging and in vascular and other diseases such as diabetes, neuropathologies and cancer.
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spelling pubmed-85774962021-11-15 Short-chain fatty acids as modulators of redox signaling in health and disease González-Bosch, Carmen Boorman, Emily Zunszain, Patricia A. Mann, Giovanni E. Redox Biol Review Article Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying SCFAs mediated protection against oxidative and mitochondrial stress and their role in regulating metabolic pathways in specific tissues. We critically evaluate the evidence for their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging. The ability of these natural compounds to induce signaling pathways, involving nuclear erythroid 2-related factor 2 (Nrf2), contributes to the maintenance of redox homeostasis under physiological conditions. SCFAs may thus serve as nutritional and therapeutic agents in healthy aging and in vascular and other diseases such as diabetes, neuropathologies and cancer. Elsevier 2021-10-14 /pmc/articles/PMC8577496/ /pubmed/34662811 http://dx.doi.org/10.1016/j.redox.2021.102165 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
González-Bosch, Carmen
Boorman, Emily
Zunszain, Patricia A.
Mann, Giovanni E.
Short-chain fatty acids as modulators of redox signaling in health and disease
title Short-chain fatty acids as modulators of redox signaling in health and disease
title_full Short-chain fatty acids as modulators of redox signaling in health and disease
title_fullStr Short-chain fatty acids as modulators of redox signaling in health and disease
title_full_unstemmed Short-chain fatty acids as modulators of redox signaling in health and disease
title_short Short-chain fatty acids as modulators of redox signaling in health and disease
title_sort short-chain fatty acids as modulators of redox signaling in health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577496/
https://www.ncbi.nlm.nih.gov/pubmed/34662811
http://dx.doi.org/10.1016/j.redox.2021.102165
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