Targeting the non‐ATP‐binding pocket of the MAP kinase p38γ mediates a novel mechanism of cytotoxicity in cutaneous T‐cell lymphoma (CTCL)

We describe here for the first time a lipid‐binding‐domain (LBD) in p38γ mitogen‐activated protein kinase (MAPK) involved in the response of T cells to a newly identified inhibitor, CSH71. We describe how CSH71, which binds to both the LBD and the ATP‐binding pocket of p38γ, is selectively cytotoxic...

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Detalles Bibliográficos
Autores principales: Zhang, Xu Hannah, Chen, Chih‐Hong, Li, Hongzhi, Hsiang, Jack, Wu, Xiwei, Hu, Weidong, Horne, David, Nam, Sangkil, Shively, Jack, Rosen, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577799/
https://www.ncbi.nlm.nih.gov/pubmed/34455585
http://dx.doi.org/10.1002/1873-3468.14186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577799/
https://www.ncbi.nlm.nih.gov/pubmed/34455585
http://dx.doi.org/10.1002/1873-3468.14186

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