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Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation

In the liver, ductal cells rarely proliferate during homeostasis but do so transiently after tissue injury. These cells can be expanded as organoids that recapitulate several of the cell-autonomous mechanisms of regeneration but lack the stromal interactions of the native tissue. Here, using organoi...

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Detalles Bibliográficos
Autores principales: Cordero-Espinoza, Lucía, Dowbaj, Anna M., Kohler, Timo N., Strauss, Bernhard, Sarlidou, Olga, Belenguer, German, Pacini, Clare, Martins, Nuno P., Dobie, Ross, Wilson-Kanamori, John R., Butler, Richard, Prior, Nicole, Serup, Palle, Jug, Florian, Henderson, Neil C., Hollfelder, Florian, Huch, Meritxell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577825/
https://www.ncbi.nlm.nih.gov/pubmed/34343491
http://dx.doi.org/10.1016/j.stem.2021.07.002