Cargando…

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy

BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-exos) have been recognized as a promising therapeutic strategy for neonatal hypoxic-ischemic brain damage (HIBD). Recently, microglial pyroptosis was shown to play a vital role in the progression of neonatal HIBD. However, whether MSC-exos impr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Zhenzhen, Yuan, Ya, Zhang, Xiuli, Lu, Yifeng, Dong, Na, Jiang, Xiuqin, Xu, Jinjin, Zheng, Datong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577931/ https://www.ncbi.nlm.nih.gov/pubmed/34765084 http://dx.doi.org/10.1155/2021/6219715

Ejemplares similares

Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats
por: Ding, Hong‐guang, et al.
Publicado: (2020)

Circulating Exosomes Mediate Neurodegeneration Following Hepatic Ischemia-reperfusion Through Inducing Microglial Pyroptosis in the Developing Hippocampus
por: Wang, Yidan, et al.
Publicado: (2023)

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway
por: Liang, Chenyu, et al.
Publicado: (2021)

Mxi1-0 regulates the growth of human umbilical vein endothelial cells through extracellular signal-regulated kinase 1/2 (ERK1/2) and interleukin-8 (IL-8)-dependent pathways
por: Wu, Weiling, et al.
Publicado: (2017)

Roles of microglial mitophagy in neurological disorders
por: Liu, Yang, et al.
Publicado: (2022)

FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion
por: Xia, Mingjie, et al.
Publicado: (2022)

Exosomal lnc-CDHR derived from human umbilical cord mesenchymal stem cells attenuates peritoneal epithelial-mesenchymal transition through AKT/FOXO pathway
por: Jiao, Taiwei, et al.
Publicado: (2023)

Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells
por: Wan, Yonghong, et al.
Publicado: (2023)

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
por: Wan, Peixing, et al.
Publicado: (2019)

MiR-149 Aggravates Pyroptosis in Myocardial Ischemia-Reperfusion Damage via Silencing FoxO3
por: Lin, Jie, et al.
Publicado: (2019)

Correction to: LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
por: Wan, Peixing, et al.
Publicado: (2022)

Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice
por: Yang, Fan, et al.
Publicado: (2022)

Human umbilical cord mesenchymal stem cell‐derived exosome suppresses programmed cell death in traumatic brain injury via PINK1/Parkin‐mediated mitophagy
por: Zhang, Li, et al.
Publicado: (2023)

Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury
por: Li, Xuefei, et al.
Publicado: (2020)

Repeated Glucose Deprivation/Reperfusion Induced PC-12 Cell Death through the Involvement of FOXO Transcription Factor
por: Han, Na, et al.
Publicado: (2016)

Exosomes Secreted by Umbilical Cord Blood-Derived Mesenchymal Stem Cell Attenuate Diabetes in Mice
por: Sharma, Rajni, et al.
Publicado: (2021)

Cardiac fibroblasts secrete exosome microRNA to suppress cardiomyocyte pyroptosis in myocardial ischemia/reperfusion injury
por: Liu, Niannian, et al.
Publicado: (2022)

Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway
por: Yan, Bing, et al.
Publicado: (2020)

Microglial Exosomes in Neurodegenerative Disease
por: Guo, Min, et al.
Publicado: (2021)

Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement
por: Wu, Chenyu, et al.
Publicado: (2020)

Human umbilical cord mesenchymal stem cells ameliorate acute liver failure by inhibiting apoptosis, inflammation and pyroptosis
por: Liu, Mengting, et al.
Publicado: (2021)

Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury
por: Shen, Luoan, et al.
Publicado: (2021)

Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage
por: Liu, Jianyang, et al.
Publicado: (2021)

Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury
por: Xiang, Qian, et al.
Publicado: (2020)

Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen–Glucose Deprivation/Reperfusion
por: Liu, Shuangxi, et al.
Publicado: (2016)

Pyroptosis in spinal cord injury
por: Yin, Jian, et al.
Publicado: (2022)

Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes
por: Dorronsoro, Akaitz, et al.
Publicado: (2013)

Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis
por: Lu, Xiao, et al.
Publicado: (2023)

Influence of placental exosomes from early onset preeclampsia women umbilical cord plasma on human umbilical vein endothelial cells
por: Gu, Mengqi, et al.
Publicado: (2022)

Comprehensive proteomic analysis of exosome mimetic vesicles and exosomes derived from human umbilical cord mesenchymal stem cells
por: Zhang, Zhaoxia, et al.
Publicado: (2022)

The role of microglial exosomes in brain injury
por: Chen, Yahong, et al.
Publicado: (2022)

The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
por: Zhao, Huijie, et al.
Publicado: (2022)

Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis
por: Tang, Jiayou, et al.
Publicado: (2020)

Exosomes Mediate Hippocampal and Cortical Neuronal Injury Induced by Hepatic Ischemia-Reperfusion Injury through Activating Pyroptosis in Rats
por: Zhang, Limei, et al.
Publicado: (2019)

Inhibition of autophagy‐dependent pyroptosis attenuates cerebral ischaemia/reperfusion injury
por: Liu, Hui, et al.
Publicado: (2021)

Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury
por: Luo, Fang, et al.
Publicado: (2022)

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury
por: Li, Qiang, et al.
Publicado: (2018)

Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy
por: Queliconi, Bruno B., et al.
Publicado: (2016)

Spheroid-cultured human umbilical cord-derived mesenchymal stem cells attenuate hepatic ischemia-reperfusion injury in rats
por: Sun, Yi, et al.
Publicado: (2018)

Pregnancy and umbilical cord pathology: structural and functional parameters of the umbilical cord
por: Dubetskyi, Bohdan Ihorovych, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m4l8cqqn2eutc1urtej2nrr614