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Network analysis reveals rare disease signatures across multiple levels of biological organization
Rare genetic diseases are typically caused by a single gene defect. Despite this clear causal relationship between genotype and phenotype, identifying the pathobiological mechanisms at various levels of biological organization remains a practical and conceptual challenge. Here, we introduce a networ...
Autores principales: | Buphamalai, Pisanu, Kokotovic, Tomislav, Nagy, Vanja, Menche, Jörg |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578255/ https://www.ncbi.nlm.nih.gov/pubmed/34753928 http://dx.doi.org/10.1038/s41467-021-26674-1 |
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