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Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA

α-Conotoxins are small disulfide-rich peptides targeting nicotinic acetylcholine receptors (nAChRs) characterised by a C(I)C(II)-X(m)-C(III)-X(n)-C(IV) framework that invariably adopt the native globular conformations which is typically most potent. α-Conotoxins are divided into several structural s...

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Detalles Bibliográficos
Autores principales: Ho, Thao N. T., Abraham, Nikita, Lewis, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578332/
https://www.ncbi.nlm.nih.gov/pubmed/34753970
http://dx.doi.org/10.1038/s41598-021-01277-4