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Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA
α-Conotoxins are small disulfide-rich peptides targeting nicotinic acetylcholine receptors (nAChRs) characterised by a C(I)C(II)-X(m)-C(III)-X(n)-C(IV) framework that invariably adopt the native globular conformations which is typically most potent. α-Conotoxins are divided into several structural s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578332/ https://www.ncbi.nlm.nih.gov/pubmed/34753970 http://dx.doi.org/10.1038/s41598-021-01277-4 |