Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function

Parkinson’s disease (PD) is characterised by the degeneration of A9 dopaminergic neurons and the pathological accumulation of alpha-synuclein. The p.A30P SNCA mutation generates the pathogenic form of the alpha-synuclein protein causing an autosomal-dominant form of PD. There are limited studies ass...

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Detalles Bibliográficos
Autores principales: Barbuti, Peter A., Ohnmacht, Jochen, Santos, Bruno F. R., Antony, Paul M., Massart, François, Cruciani, Gérald, Dording, Claire M., Pavelka, Lukas, Casadei, Nicolas, Kwon, Yong-Jun, Krüger, Rejko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578337/
https://www.ncbi.nlm.nih.gov/pubmed/34754035
http://dx.doi.org/10.1038/s41598-021-01505-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578337/
https://www.ncbi.nlm.nih.gov/pubmed/34754035
http://dx.doi.org/10.1038/s41598-021-01505-x

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