Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replication-competent recombinant viruses, rVSV-SARS-CoV-2 and rVSV-SARS-CoV. Using wild-type and...

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Detalles Bibliográficos
Autores principales: Li, Hongyue, Zhang, Yuhang, Li, Dong, Deng, Yong-Qiang, Xu, Hongde, Zhao, Chaoyue, Liu, Jiandong, Wen, Dan, Zhao, Jianguo, Li, Yongchun, Wu, Yong, Liu, Shujun, Liu, Jiankai, Hao, Junfeng, Yuan, Fei, Duo, Shuguang, Qin, Cheng-Feng, Zheng, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578532/
https://www.ncbi.nlm.nih.gov/pubmed/34759261
http://dx.doi.org/10.1038/s41392-021-00797-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578532/
https://www.ncbi.nlm.nih.gov/pubmed/34759261
http://dx.doi.org/10.1038/s41392-021-00797-9

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