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A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1

Identification of vulnerable sites defined by broadly neutralizing antibodies (bNAbs) on HIV-1 envelope (Env) is crucial for vaccine design, and we present here a vulnerable site defined by bNAb M4008_N1, which neutralizes about 40% of a tier-2 virus panel. A 3.2 Å resolution cryo-EM structure of M4...

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Detalles Bibliográficos
Autores principales: Chan, Kun-Wei, Luo, Christina C., Lu, Hong, Wu, Xueling, Kong, Xiang-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578649/
https://www.ncbi.nlm.nih.gov/pubmed/34753944
http://dx.doi.org/10.1038/s41467-021-26846-z