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Impact of Antibiotics and Proton Pump Inhibitors on Efficacy and Tolerance of Anti-PD-1 Immune Checkpoint Inhibitors

BACKGROUND: The use of antibiotics (ATB) and proton-pump inhibitors (PPI) alters the composition and diversity of the gut microbiota, which can influence the immune system, consequently interfering with response to anti-PD1 immune checkpoint inhibitors (ICI). We assessed the impact of ATB and/or PPI...

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Detalles Bibliográficos
Autores principales: Giordan, Quentin, Salleron, Julia, Vallance, Catherine, Moriana, Clothilde, Clement-Duchene, Christelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578856/
https://www.ncbi.nlm.nih.gov/pubmed/34777340
http://dx.doi.org/10.3389/fimmu.2021.716317