HMGB1 Promotes Resistance to Doxorubicin in Human Hepatocellular Carcinoma Cells by Inducing Autophagy via the AMPK/mTOR Signaling Pathway

Chemoresistance remains as a major hindrance in the treatment of hepatocellular carcinoma (HCC). High mobility group box protein 1 (HMGB1) enhances autophagic flux and protects tumor cells from apoptosis, which results in acquired drug resistance. However, the exact mechanisms underlying HMGB1-modul...

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Detalles Bibliográficos
Autores principales: Li, Junhua, Zhou, Wei, Mao, Qiang, Gao, Dandan, Xiong, Lin, Hu, Xinyao, Zheng, Yongfa, Xu, Ximing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578906/
https://www.ncbi.nlm.nih.gov/pubmed/34778055
http://dx.doi.org/10.3389/fonc.2021.739145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578906/
https://www.ncbi.nlm.nih.gov/pubmed/34778055
http://dx.doi.org/10.3389/fonc.2021.739145

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