VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense desmoplastic stroma that limits the delivery of anticancer agents. VCN-01 is an oncolytic adenovirus designed to replicate in cancer cells with a dysfunctional RB1 pathway and express hyaluronidase. Here, we evaluated the...

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Detalles Bibliográficos
Autores principales: Bazan-Peregrino, Miriam, Garcia-Carbonero, Rocio, Laquente, Berta, Álvarez, Rafael, Mato-Berciano, Ana, Gimenez-Alejandre, Marta, Morgado, Sara, Rodríguez-García, Alba, Maliandi, Maria V, Riesco, M Carmen, Moreno, Rafael, Ginestà, Mireia M, Perez-Carreras, Mercedes, Gornals, Joan B, Prados, Susana, Perea, Sofía, Capella, Gabriel, Alemany, Ramon, Salazar, Ramon, Blasi, Emma, Blasco, Carmen, Cascallo, Manel, Hidalgo, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578996/
https://www.ncbi.nlm.nih.gov/pubmed/35149591
http://dx.doi.org/10.1136/jitc-2021-003254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578996/
https://www.ncbi.nlm.nih.gov/pubmed/35149591
http://dx.doi.org/10.1136/jitc-2021-003254

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