Accumulation of cholesterol suppresses oxidative phosphorylation and altered responses to inflammatory stimuli of macrophages

Hypercholesterolemia induces intracellular accumulation of cholesterol in macrophages and other immune cells, causing immunological dysfunctions. On cellular levels, cholesterol enrichment might lead to mitochondrial metabolic reprogramming and change macrophage functions. Additionally, as cholester...

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Detalles Bibliográficos
Autores principales: Chiu, Yi-Chou, Chu, Pei-Wen, Lin, Hua-Ching, Chen, Shau-Kwaun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579117/
https://www.ncbi.nlm.nih.gov/pubmed/34786493
http://dx.doi.org/10.1016/j.bbrep.2021.101166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579117/
https://www.ncbi.nlm.nih.gov/pubmed/34786493
http://dx.doi.org/10.1016/j.bbrep.2021.101166

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