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The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis

High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of genomic instability associated with large number of genetic alterations. BRD4 is the 4th most amplified gene in HGSOC, which correlat...

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Detalles Bibliográficos
Autores principales: Drumond-Bock, Ana Luiza, Bieniasz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579545/
https://www.ncbi.nlm.nih.gov/pubmed/34758842
http://dx.doi.org/10.1186/s12943-021-01424-5