The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions

During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in Staphylococcus aureus. These enzymes are cofactors in rib...

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Detalles Bibliográficos
Autores principales: Bennison, Daniel J., Nakamoto, Jose A., Craggs, Timothy D., Milón, Pohl, Rafferty, John B., Corrigan, Rebecca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579695/
https://www.ncbi.nlm.nih.gov/pubmed/34749534
http://dx.doi.org/10.1128/mBio.02679-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579695/
https://www.ncbi.nlm.nih.gov/pubmed/34749534
http://dx.doi.org/10.1128/mBio.02679-21

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