In Vitro Evolution of Cefiderocol Resistance in an NDM-Producing Klebsiella pneumoniae Due to Functional Loss of CirA

By serially exposing an NDM-producing Klebsiella pneumoniae clinical strain to cefiderocol, we obtained a mutant with cefiderocol MIC of >128 μg/ml. The mutant contained an early stop codon in the iron transporter gene cirA, and its complementation fully restored susceptibility. The cirA-deficien...

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Detalles Bibliográficos
Autores principales: McElheny, Christi L., Fowler, Erin L., Iovleva, Alina, Shields, Ryan K., Doi, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579844/
https://www.ncbi.nlm.nih.gov/pubmed/34756080
http://dx.doi.org/10.1128/Spectrum.01779-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579844/
https://www.ncbi.nlm.nih.gov/pubmed/34756080
http://dx.doi.org/10.1128/Spectrum.01779-21

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