Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

Human islet amyloid polypeptide (hIAPP) functions as a glucose-regulating hormone, but deposits as amyloid fibrils in more than 90% of Type-II Diabetes (T2D) patients. Here we report the cryo-EM structure of recombinant full-length hIAPP fibrils. The fibril is composed of two symmetrically related p...

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Detalles Bibliográficos
Autores principales: Cao, Qin, Boyer, David R., Sawaya, Michael R., Ge, Peng, Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579859/
https://www.ncbi.nlm.nih.gov/pubmed/32541896
http://dx.doi.org/10.1038/s41594-020-0435-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579859/
https://www.ncbi.nlm.nih.gov/pubmed/32541896
http://dx.doi.org/10.1038/s41594-020-0435-3

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