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CRISPR/Cas9 in zebrafish: An attractive model for FBN1 genetic defects in humans
BACKGROUND: Mutations in the fibrillin‐1 gene (FBN1) are associated with various heritable connective tissue disorders (HCTD). The most studied HCTD is Marfan syndrome. Ninety percent of Marfan syndrome is caused by mutations in the FBN1 gene. The zebrafish share high genetic similarity to humans, r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580104/ https://www.ncbi.nlm.nih.gov/pubmed/34324266 http://dx.doi.org/10.1002/mgg3.1775 |