Cargando…
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis
Osteoarthritis (OA), characterized by chronic systemic low-level inflammation and cartilage degeneration, is a type of arthritis closely associated with aging. Inflammation and aging play a pivotal role in the occurrence and progression of OA. NLRP3 inflammasome is involved in many inflammatory and...
Autores principales: | Ni, Bowei, Pei, Wenbin, Qu, Yunkun, Zhang, Rui, Chu, Xiangyu, Wang, Yingguang, Huang, Xiaojian, You, Hongbo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580635/ https://www.ncbi.nlm.nih.gov/pubmed/34777685 http://dx.doi.org/10.1155/2021/4139048 |
Ejemplares similares
-
MCC950 closes the active conformation of NLRP3 to an inactive
state
por: Tapia-Abellán, Ana, et al.
Publicado: (2019) -
Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice
por: Ren, Pingping, et al.
Publicado: (2020) -
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis
por: Pei, Wenbin, et al.
Publicado: (2021) -
Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice
por: Zhai, Yadong, et al.
Publicado: (2018) -
The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages
por: Zeng, Wenyun, et al.
Publicado: (2021)