GPCR activation mechanisms across classes and macro/microscales

Two-thirds of human hormones and one-third of clinical drugs activate ~350 G-protein-coupled receptors (GPCR) belonging to four classes: A, B1, C and F. Whereas a model of activation has been described for class A, very little is known about the activation of the other classes, which differ by being...

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Detalles Bibliográficos
Autores principales: Hauser, Alexander S., Kooistra, Albert J., Munk, Christian, Heydenreich, Franziska M., Veprintsev, Dmitry B., Bouvier, Michel, Babu, M. Madan, Gloriam, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580822/
https://www.ncbi.nlm.nih.gov/pubmed/34759375
http://dx.doi.org/10.1038/s41594-021-00674-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580822/
https://www.ncbi.nlm.nih.gov/pubmed/34759375
http://dx.doi.org/10.1038/s41594-021-00674-7

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