A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps)

Cytochrome P450 (CYP) is the most important phase I drug-metabolizing enzyme, and the effect of drugs on CYP enzymes can lead to decreased pharmacological efficacy or enhanced toxicity of drugs, but there are many deficiencies in the evaluation models of CYP enzymes in vitro. Human-induced hepatocyt...

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Detalles Bibliográficos
Autores principales: Li, Yan, Lu, Ying-Yuan, Jia, Jun, Fang, Meng, Zhao, Lin, Jiang, Yong, Shi, Yan, Tu, Peng-Fei, Guo, Xiao-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580884/
https://www.ncbi.nlm.nih.gov/pubmed/34776966
http://dx.doi.org/10.3389/fphar.2021.748658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580884/
https://www.ncbi.nlm.nih.gov/pubmed/34776966
http://dx.doi.org/10.3389/fphar.2021.748658

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