Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells

Tbx3 has been identified as a regulator of liver development in the mouse, but its function in human liver development remains unknown. TBX3 mutant human pluripotent stem cell (PSC) lines were generated using CRISPR/Cas9 genome editing. TBX3 loss led to impaired liver differentiation and an upregula...

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Detalles Bibliográficos
Autores principales: Mukherjee, Somdutta, French, Deborah L., Gadue, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580886/
https://www.ncbi.nlm.nih.gov/pubmed/34653400
http://dx.doi.org/10.1016/j.stemcr.2021.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580886/
https://www.ncbi.nlm.nih.gov/pubmed/34653400
http://dx.doi.org/10.1016/j.stemcr.2021.09.004

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