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Kinetics of alpha-synuclein depletion in three brain regions following conditional pan-neuronal inactivation of the encoding gene (Snca) by tamoxifen-induced Cre-recombination in adult mice

Conditional pan-neuronal inactivation of the Snca gene in 2-month old male and female mice causes dramatic decrease in the level of the encoded protein, alpha-synuclein, in three studied brain regions, namely cerebral cortex, midbrain and striatum, 12 weeks after the last injection of tamoxifen. Kin...

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Detalles Bibliográficos
Autores principales: Chaprov, Kirill D., Lysikova, Ekaterina A., Teterina, Ekaterina V., Buchman, Vladimir L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580898/
https://www.ncbi.nlm.nih.gov/pubmed/34590209
http://dx.doi.org/10.1007/s11248-021-00286-3