Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice

Opioid drugs are widely used analgesics that activate the G protein-coupled µ-opioid receptor, whose endogenous neuropeptide agonists, endorphins and enkephalins, are potent pain relievers. The therapeutic utility of opioid drugs is hindered by development of tolerance to the analgesic effects, requ...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Li, Gooding, Sarah W., Lewis, Elinor, Felth, Lindsey C., Gaur, Anirudh, Whistler, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581001/
https://www.ncbi.nlm.nih.gov/pubmed/34257415
http://dx.doi.org/10.1038/s41386-021-01054-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581001/
https://www.ncbi.nlm.nih.gov/pubmed/34257415
http://dx.doi.org/10.1038/s41386-021-01054-x

Ejemplares similares