Cargando…

Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice

Opioid drugs are widely used analgesics that activate the G protein-coupled µ-opioid receptor, whose endogenous neuropeptide agonists, endorphins and enkephalins, are potent pain relievers. The therapeutic utility of opioid drugs is hindered by development of tolerance to the analgesic effects, requ...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Li, Gooding, Sarah W., Lewis, Elinor, Felth, Lindsey C., Gaur, Anirudh, Whistler, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581001/ https://www.ncbi.nlm.nih.gov/pubmed/34257415 http://dx.doi.org/10.1038/s41386-021-01054-x

Ejemplares similares

Characterization of methadone as a β-arrestin-biased μ-opioid receptor agonist
por: Doi, Seira, et al.
Publicado: (2016)

Usefulness for the combination of G protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance
por: Mori, Tomohisa, et al.
Publicado: (2017)

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
por: Puls, Kristina, et al.
Publicado: (2022)

Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2
por: Lam, Hoa, et al.
Publicado: (2011)

β-Arrestin 2 and ERK1/2 Are Important Mediators Engaged in Close Cooperation between TRPV1 and µ-Opioid Receptors in the Plasma Membrane
por: Melkes, Barbora, et al.
Publicado: (2020)

Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation
por: Piekielna-Ciesielska, Justyna, et al.
Publicado: (2020)

Pharmacological Profiles of Oligomerized μ-Opioid Receptors
por: Lee, Cynthia Wei-Sheng, et al.
Publicado: (2013)

Does ‘Strong Analgesic’ Equal ‘Strong Opioid’? Tapentadol and the Concept of ‘µ-Load’
por: Raffa, Robert B., et al.
Publicado: (2018)

Tail engagement of arrestin at the glucagon receptor
por: Chen, Kun, et al.
Publicado: (2023)

Anti-Analgesic Effect of the Mu/Delta Opioid Receptor Heteromer Revealed by Ligand-Biased Antagonism
por: Milan-Lobo, Laura, et al.
Publicado: (2013)

Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain
por: Király, Kornél, et al.
Publicado: (2021)

Loss of μ-opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesic efficacy
por: Corder, Gregory, et al.
Publicado: (2017)

μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges
por: Salinsky, Leah M., et al.
Publicado: (2023)

Risk of asthma exacerbation associated with opioid and nonopioid analgesic use in children with current asthma
por: Nair, Abhishek A, et al.
Publicado: (2022)

In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel μ opioid analgesic with reduced propensity to alter motor function
por: Spetea, Mariana, et al.
Publicado: (2010)

Chronic Ethanol Consumption in Rats Produces Opioid Antinociceptive Tolerance through Inhibition of Mu Opioid Receptor Endocytosis
por: He, Li, et al.
Publicado: (2011)

A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor
por: Dekan, Zoltan, et al.
Publicado: (2019)

Tolerance to Non-Opioid Analgesics is Opioid Sensitive in the Nucleus Raphe Magnus
por: Tsagareli, Merab G., et al.
Publicado: (2011)

Assessment of Potentially Inappropriate Prescribing of Opioid Analgesics Requiring Prior Opioid Tolerance
por: Jeffery, Molly Moore, et al.
Publicado: (2020)

Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated
por: Bai, Xue, et al.
Publicado: (2022)

The relationship between the level of μ-opioid receptor (μORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trial
por: Gencer, Muzaffer, et al.
Publicado: (2020)

Pharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation
por: Floettmann, Eike, et al.
Publicado: (2017)

Regulation of opioid receptor signalling: Implications for the development of analgesic tolerance
por: Nagi, Karim, et al.
Publicado: (2011)

Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice
por: Cinque, C, et al.
Publicado: (2012)

Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics
por: Bedini, Andrea, et al.
Publicado: (2022)

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics
por: McLaughlin, Jay P., et al.
Publicado: (2022)

Cellular tolerance at the µ-opioid receptor is phosphorylation dependent
por: Arttamangkul, Seksiri, et al.
Publicado: (2018)

Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain
por: Rodriguez-Gaztelumendi, Antonio, et al.
Publicado: (2018)

µ-Conotoxins as Leads in the Development of New Analgesics
por: Norton, Raymond S.
Publicado: (2010)

Functional competence of a partially engaged GPCR–β-arrestin complex
por: Kumari, Punita, et al.
Publicado: (2016)

Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist
por: Wang, Yu-Hua, et al.
Publicado: (2018)

ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression
por: Bachmutsky, Iris, et al.
Publicado: (2021)

Pharmacogenomics and Opioid Analgesics: Clinical Implications
por: Yiannakopoulou, Eugenia
Publicado: (2015)

Caffeine as an opioid analgesic adjuvant in fibromyalgia
por: Scott, J Ryan, et al.
Publicado: (2017)

Non-opioid Analgesics and the Endocannabinoid System
por: Topuz, Ruhan Deniz, et al.
Publicado: (2020)

Opioid Sparing Analgesics in Spine Surgery
por: Reed, Logan A., et al.
Publicado: (2022)

Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics
por: Ueda, Hiroshi
Publicado: (2021)

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation
por: Kanemasa, Toshiyuki, et al.
Publicado: (2019)

Loss of Astrocytic µ Opioid Receptors Exacerbates Aversion Associated with Morphine Withdrawal in Mice: Role of Mitochondrial Respiration
por: Murlanova, Kateryna, et al.
Publicado: (2023)

MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2
por: Wu, Xian-Ping, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6f0472hsnisfimvqn4grj8mcnj