Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes

We propose a new concept that human somatic cells can be converted to become male germline stem cells by the defined factors. Here, we demonstrated that the overexpression of DAZL, DAZ2, and BOULE could directly reprogram human Sertoli cells into cells with the characteristics of human spermatogonia...

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Detalles Bibliográficos
Autores principales: Zhang, Wenhui, Chen, Wei, Cui, Yinghong, Wen, Liping, Yuan, Qingqing, Zhou, Fan, Qiu, Qianqian, Sun, Min, Li, Zheng, He, Zuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581058/
https://www.ncbi.nlm.nih.gov/pubmed/34653405
http://dx.doi.org/10.1016/j.stemcr.2021.09.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581058/
https://www.ncbi.nlm.nih.gov/pubmed/34653405
http://dx.doi.org/10.1016/j.stemcr.2021.09.011

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