CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes

Calreticulin (CALR) mutations are driver mutations in myeloproliferative neoplasms (MPNs), leading to activation of the thrombopoietin receptor and causing abnormal megakaryopoiesis. Here, we generated patient-derived CALRins5- or CALRdel52-positive induced pluripotent stem cells (iPSCs) to establis...

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Detalles Bibliográficos
Autores principales: Olschok, Kathrin, Han, Lijuan, de Toledo, Marcelo A.S., Böhnke, Janik, Graßhoff, Martin, Costa, Ivan G., Theocharides, Alexandre, Maurer, Angela, Schüler, Herdit M., Buhl, Eva Miriam, Pannen, Kristina, Baumeister, Julian, Kalmer, Milena, Gupta, Siddharth, Boor, Peter, Gezer, Deniz, Brümmendorf, Tim H., Zenke, Martin, Chatain, Nicolas, Koschmieder, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581168/
https://www.ncbi.nlm.nih.gov/pubmed/34678208
http://dx.doi.org/10.1016/j.stemcr.2021.09.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581168/
https://www.ncbi.nlm.nih.gov/pubmed/34678208
http://dx.doi.org/10.1016/j.stemcr.2021.09.019

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