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CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes
Calreticulin (CALR) mutations are driver mutations in myeloproliferative neoplasms (MPNs), leading to activation of the thrombopoietin receptor and causing abnormal megakaryopoiesis. Here, we generated patient-derived CALRins5- or CALRdel52-positive induced pluripotent stem cells (iPSCs) to establis...
Autores principales: | Olschok, Kathrin, Han, Lijuan, de Toledo, Marcelo A.S., Böhnke, Janik, Graßhoff, Martin, Costa, Ivan G., Theocharides, Alexandre, Maurer, Angela, Schüler, Herdit M., Buhl, Eva Miriam, Pannen, Kristina, Baumeister, Julian, Kalmer, Milena, Gupta, Siddharth, Boor, Peter, Gezer, Deniz, Brümmendorf, Tim H., Zenke, Martin, Chatain, Nicolas, Koschmieder, Steffen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581168/ https://www.ncbi.nlm.nih.gov/pubmed/34678208 http://dx.doi.org/10.1016/j.stemcr.2021.09.019 |
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