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Fumarylacetoacetate hydrolase gene as a knockout target for hepatic chimerism and donor liver production

A reliable source of human hepatocytes and transplantable livers is needed. Interspecies embryo complementation, which involves implanting donor human stem cells into early morula/blastocyst stage animal embryos, is an emerging solution to the shortage of transplantable livers. We review proposed mu...

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Detalles Bibliográficos
Autores principales: Larson, Ellen L., Joo, Dong Jin, Nelson, Erek D., Amiot, Bruce P., Aravalli, Rajagopal N., Nyberg, Scott L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581169/
https://www.ncbi.nlm.nih.gov/pubmed/34678209
http://dx.doi.org/10.1016/j.stemcr.2021.09.018