p53 inactivation unmasks histone methylation-independent WDR5 functions that drive self-renewal and differentiation of pluripotent stem cells

p53 alterations occur during culture of pluripotent stem cells (PSCs), but the significance of these events on epigenetic control of PSC fate determination remains poorly understood. Wdr5 deletion in p53-null (DKO) mouse ESCs (mESCs) leads to impaired self-renewal, defective retinal neuroectoderm di...

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Detalles Bibliográficos
Autores principales: Li, Qiang, Huang, Yuanhao, Xu, Jing, Mao, Fengbiao, Zhou, Bo, Sun, Lichao, Basinski, Brian W., Aksu, Michael, Liu, Jie, Dou, Yali, Rao, Rajesh C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581203/
https://www.ncbi.nlm.nih.gov/pubmed/34715053
http://dx.doi.org/10.1016/j.stemcr.2021.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581203/
https://www.ncbi.nlm.nih.gov/pubmed/34715053
http://dx.doi.org/10.1016/j.stemcr.2021.10.002

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