Targeting DYRK1A/B kinases to modulate p21‐cyclin D1‐p27 signalling and induce anti‐tumour activity in a model of human glioblastoma

The dual‐specificity tyrosine‐regulated kinases DYRK1A and DYRK1B play a key role in controlling the quiescence‐proliferation switch in cancer cells. Serum reduction of U87MG 2D cultures or multi‐cellular tumour spheroids induced a quiescent like state characterized by increased DYRK1B and p27, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Massey, Andrew J., Benwell, Karen, Burbridge, Mike, Kotschy, Andras, Walmsley, David Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581321/
https://www.ncbi.nlm.nih.gov/pubmed/34708541
http://dx.doi.org/10.1111/jcmm.17002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581321/
https://www.ncbi.nlm.nih.gov/pubmed/34708541
http://dx.doi.org/10.1111/jcmm.17002

Ejemplares similares