Cargando…

Targeting DYRK1A/B kinases to modulate p21‐cyclin D1‐p27 signalling and induce anti‐tumour activity in a model of human glioblastoma

The dual‐specificity tyrosine‐regulated kinases DYRK1A and DYRK1B play a key role in controlling the quiescence‐proliferation switch in cancer cells. Serum reduction of U87MG 2D cultures or multi‐cellular tumour spheroids induced a quiescent like state characterized by increased DYRK1B and p27, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Massey, Andrew J., Benwell, Karen, Burbridge, Mike, Kotschy, Andras, Walmsley, David Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581321/ https://www.ncbi.nlm.nih.gov/pubmed/34708541 http://dx.doi.org/10.1111/jcmm.17002

Ejemplares similares

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation
por: Soppa, Ulf, et al.
Publicado: (2014)

A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21
por: Bélanger, François, et al.
Publicado: (2023)

Expression of cyclin dependent kinase inhibitor p21WAF1 alone and in combination with p27KIP1 shows prognostic value in gastric carcinoma.
por: Jang, S. J., et al.
Publicado: (1998)

Expression of cyclin-dependent kinase inhibitor p27kip1 in malignant lymphomas.
por: Oh, Y. H., et al.
Publicado: (2000)

The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouse
por: Bayrak, Aykut, et al.
Publicado: (2003)

Cyclin-dependent kinase inhibitors p21 and p27 function as critical regulators of liver regeneration following 90% hepatectomy in the rat
por: Moniaux, Nicolas, et al.
Publicado: (2020)

Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1
por: Movassagh, Mehregan, et al.
Publicado: (2008)

Increased Expression of Cyclin D1, Cyclin E and p21(Cip1) Associated with Decreased Expression of p27(Kip1) in Chemically Induced Rat Mammary Carcinogenesis
por: Jang, Tae Jung, et al.
Publicado: (2000)

p27(Kip1) and p21(Cip1) collaborate in the regulation of transcription by recruiting cyclin–Cdk complexes on the promoters of target genes
por: Orlando, Serena, et al.
Publicado: (2015)

Upregulation of p27 cyclin-dependent kinase inhibitor and a C-terminus truncated form of p27 contributes to G1 phase arrest
por: Satoh, Takayuki, et al.
Publicado: (2016)

PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27(Kip1)
por: Pérez-Luna, Maria, et al.
Publicado: (2012)

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
por: Papenfuss, Marco, et al.
Publicado: (2022)

Mitotic p21(Cip1/CDKN1A) is regulated by cyclin-dependent kinase 1 phosphorylation
por: Kreis, Nina-Naomi, et al.
Publicado: (2016)

The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin L2 To Control HIV Replication in Macrophages
por: Kisaka, Javan K., et al.
Publicado: (2020)

Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers
por: Hur, Saem, et al.
Publicado: (2020)

Reciprocal role of cyclins and cyclin kinase inhibitor p21(WAF1/CIP1 )on lymphocyte proliferation, allo-immune activation and inflammation
por: Khanna, Ashwani K
Publicado: (2005)

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A
por: Widowati, Esti Wahyu, et al.
Publicado: (2018)

DYRK1A activates NFATC1 to increase glioblastoma migration
por: Liu, Heng, et al.
Publicado: (2021)

Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A
por: Marti, Guillaume, et al.
Publicado: (2013)

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27(KIP1)
por: St. Croix, Brad, et al.
Publicado: (1998)

Cyclin-Dependent Kinase Inhibitor P27(Kip1) Is Required for Mouse Mammary Gland Morphogenesis and Function
por: Muraoka, Rebecca S., et al.
Publicado: (2001)

Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1
por: Liu, Shuang, et al.
Publicado: (2012)

The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer
por: Chiarle, Roberto, et al.
Publicado: (2001)

Mirk/dyrk1B Kinase in Ovarian Cancer
por: Friedman, Eileen
Publicado: (2013)

Cux1 regulation of the cyclin kinase inhibitor p27(kip1) in polycystic kidney disease is attenuated by HDAC inhibitors
por: Livingston, Safia, et al.
Publicado: (2019)

Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27(Kip1)
por: Harrison, Theresa A, et al.
Publicado: (2011)

Editor's Note on ‘PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27(Kip1)’
Publicado: (2023)

Expression of Cyclin‐dependent Kinase Inhibitor p27/Kipl and AP‐1 Coactivator p38/Jabl Correlates with Differentiation of Embryonal Rhabdomyosarcoma
por: Tsuchida, Rika, et al.
Publicado: (2002)

Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells
por: Komata, T, et al.
Publicado: (2003)

Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers
por: Minarikova, Petra, et al.
Publicado: (2016)

FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21
por: Yamada, Kayo, et al.
Publicado: (2013)

The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target
por: Rammohan, Malini, et al.
Publicado: (2022)

The cyclin dependent kinase inhibitor p21(Cip1/Waf1) is a therapeutic target in high-risk neuroblastoma
por: Sorteberg, Agnes Luise, et al.
Publicado: (2022)

Cyclin D1 Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome
por: Smith, Ian, et al.
Publicado: (2015)

Cyclin-Dependent Kinase Inhibitor p27(Kip1) Controls Growth and Cell Cycle Progression in Human Uterine Leiomyoma
por: Ramachandran, Sabarish, et al.
Publicado: (2008)

Phosphorylation of p27(Kip1) at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation
por: Zheng, Ya-Li, et al.
Publicado: (2010)

Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A (p21) gene by NFI in proliferating human cells
por: Ouellet, Stéphane, et al.
Publicado: (2006)

Transcriptional regulation of cyclin-dependent kinase inhibitor 1A (P21) by the transcription factor AP-2γ
por: Scibetta, AG, et al.
Publicado: (2010)

Cyclin Kinase-independent role of p21(CDKN1A) in the promotion of nascent DNA elongation in unstressed cells
por: Mansilla, Sabrina F, et al.
Publicado: (2016)

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27(Kip1 )or p21(Cip1)
por: Zhuang, Yongxian, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_o06mauvpprt16i0emse7hs1m08