Cargando…

ERK5 signalling pathway is a novel target of sorafenib: Implication in EGF biology

Sorafenib is a multikinase inhibitor widely used in cancer therapy with an antitumour effect related to biological processes as proliferation, migration or invasion, among others. Initially designed as a Raf inhibitor, Sorafenib was later shown to also block key molecules in tumour progression such...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ortega‐Muelas, Marta, Roche, Olga, Fernández‐Aroca, Diego M., Encinar, José A., Albandea‐Rodríguez, David, Arconada‐Luque, Elena, Pascual‐Serra, Raquel, Muñoz, Ismael, Sánchez‐Pérez, Isabel, Belandia, Borja, Ruiz‐Hidalgo, María J., Sánchez‐Prieto, Ricardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581332/ https://www.ncbi.nlm.nih.gov/pubmed/34655447 http://dx.doi.org/10.1111/jcmm.16990

Ejemplares similares

Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion
por: Serrano-Oviedo, Leticia, et al.
Publicado: (2018)

ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
por: Arconada-Luque, Elena, et al.
Publicado: (2022)

p38MAPK and Chemotherapy: We Always Need to Hear Both Sides of the Story
por: García-Cano, Jesús, et al.
Publicado: (2016)

p38β and Cancer: The Beginning of the Road
por: Roche, Olga, et al.
Publicado: (2020)

Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications
por: Sánchez-Fdez, Adrián, et al.
Publicado: (2023)

P38 MAPK and Radiotherapy: Foes or Friends?
por: García-Flores, Natalia, et al.
Publicado: (2023)

Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance
por: García-Cano, Jesús, et al.
Publicado: (2015)

MAPK11 (p38β) is a major determinant of cellular radiosensitivity by controlling ionizing radiation-associated senescence: An in vitro study
por: Fernández-Aroca, D.M., et al.
Publicado: (2023)

SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR
por: Thomas, J. Terrig, et al.
Publicado: (2016)

Nuclear receptor regulation gears up another Notch
por: Belandia, Borja, et al.
Publicado: (2006)

MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells
por: Cimas, Francisco J., et al.
Publicado: (2015)

Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway
por: Gunawardhana, Niluka, et al.
Publicado: (2018)

Acute Downregulation of ENaC by EGF Involves the PY Motif and Putative ERK Phosphorylation Site
por: Falin, Rebecca A., et al.
Publicado: (2007)

Phosphorylated ERK is a potential prognostic biomarker for Sorafenib response in hepatocellular carcinoma
por: Liang, Yuelong, et al.
Publicado: (2017)

Modulation of Autophagy by Sorafenib: Effects on Treatment Response
por: Prieto-Domínguez, Nestor, et al.
Publicado: (2016)

Shoc2 Is Targeted to Late Endosomes and Required for Erk1/2 Activation in EGF-Stimulated Cells
por: Galperin, Emilia, et al.
Publicado: (2012)

Calcium Regulation of EGF-Induced ERK5 Activation: Role of Lad1-MEKK2 Interaction
por: Yao, Zhong, et al.
Publicado: (2010)

P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling
por: Queipo, Mª José, et al.
Publicado: (2018)

EGF and HB-EGF enhance the proliferation of programmable cells of monocytic origin (PCMO) through activation of MEK/ERK signaling and improve differentiation of PCMO-derived hepatocyte-like cells
por: Hyder, Ayman, et al.
Publicado: (2012)

EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells
por: Wang, Haijuan, et al.
Publicado: (2010)

Colorectal cancer cells promote osteoclastogenesis and bone destruction through regulating EGF/ERK/CCL3 pathway
por: Zi-chen, Gong, et al.
Publicado: (2020)

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling
por: Sheng, Weiwei, et al.
Publicado: (2020)

Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathway
por: Indramanee, Somsiri, et al.
Publicado: (2019)

Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF–ERK1/2 signaling pathways
por: Jeon, Miji, et al.
Publicado: (2022)

Sorafenib Inhibits Lymphoma Xenografts by Targeting MAPK/ERK and AKT Pathways in Tumor and Vascular Cells
por: Carlo-Stella, Carmelo, et al.
Publicado: (2013)

Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint
por: Chen, Jiang, et al.
Publicado: (2016)

Los pobres contra los ricos /
por: Arconada, César Muñoz, 1900-1964
Publicado: (1977)

Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: Indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases
por: Finch, Ann R., et al.
Publicado: (2012)

Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway
por: Sheng, Weiwei, et al.
Publicado: (2017)

Correction to: Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling
por: Sheng, Weiwei, et al.
Publicado: (2020)

EGF Receptor Transactivation by Endothelin-1 Increased CHSY-1 Mediated by NADPH Oxidase and Phosphorylation of ERK1/2
por: Babaahmadi-Rezaei, Hossein, et al.
Publicado: (2021)

Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways
por: Wang, Wenbo, et al.
Publicado: (2016)

Sorafenib inhibited cell growth through the MEK/ERK signaling pathway in acute promyelocytic leukemia cells
por: Zhang, Yunjie, et al.
Publicado: (2018)

TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC
por: Sun, Huimin, et al.
Publicado: (2022)

Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
por: Takao, Tomoka, et al.
Publicado: (2022)

EGF is internalized and degraded
por: Leslie, Mitch
Publicado: (2005)

Ligand regulation of a constitutively dimeric EGF receptor
por: Freed, Daniel M., et al.
Publicado: (2015)

Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
por: Liu, Ning Sheng, et al.
Publicado: (2009)

Effect of blockade of the EGF system on wound healing in patients vaccinated with CIMAvax® EGF
por: Fernández Lorente, Aymara, et al.
Publicado: (2013)

Cell-Based Sensors for the Detection of EGF and EGF-Stimulated Ca(2+) Signaling
por: Lee, Euiyeon, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2gv2o5f93ek7hvkeqk7nhhsrpl