PKM2 promotes angiotensin‐II‐induced cardiac remodelling by activating TGF‐β/Smad2/3 and Jak2/Stat3 pathways through oxidative stress

Hypertensive cardiac remodelling is a common cause of heart failure. However, the molecular mechanisms regulating cardiac remodelling remain unclear. Pyruvate kinase isozyme type M2 (PKM2) is a key regulator of the processes of glycolysis and oxidative phosphorylation, but the roles in cardiac remod...

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Detalles Bibliográficos
Autores principales: Zhang, Xiyu, Zheng, Cuiting, Gao, Zhenqiang, Wang, Lingling, Chen, Chen, Zheng, Yuanyuan, Meng, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581335/
https://www.ncbi.nlm.nih.gov/pubmed/34687136
http://dx.doi.org/10.1111/jcmm.17007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581335/
https://www.ncbi.nlm.nih.gov/pubmed/34687136
http://dx.doi.org/10.1111/jcmm.17007

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